OpenNitro can be installed on servers hosting mulptiple sites, without having to install the codebase multiple times. Just unpack the OpenNitro source code in a shared directory (for instance /usr/local/OpeNitro/). For every site you have that uses OpenNitro you only have to copy the html directory to the document root of the site and create an ini with the approriate settings (see default ini's in the OpenNitro root directory).